Bernie is a famous stand-up comedian living the good life in his Los Angeles home. Life was simple and sweet for the Mac-Man. Then one day Bernie's sister in Chicago is sent on a 'state-sponsored vacation' (rehab) for drug use and her three children: teenage adolescent Vanessa, asthmatic weaseling Jordan, and sweet, innocent Bryana, are taken into Bernie's custody. Raising kids is hard and these three are always giving poor Uncle Bernie trouble.