When Caillou gets sick, he has to go see the doctor.

Ms. Frizzle takes her class on a field trip to learn all about the inside of the human body.

When the Magic School Bus takes a dive, Wanda discovers that one of Ms. Frizzle's ancestors was Redbeard the Pirate and a treasure map leads the class to a coral reef where they learn first hand that life there is risky. In The Magic School Bus gets swamped, the class learns that swampland is an important haitat and natural water filter. In the Magic School Bus goes to Mussel Beach, the class learns about life along a shore.

As Ms. Frizzle leads the way, the class takes an action-packed journey through Arnold's digestive system (For lunch), a pulsating excursion through Ralphie's bloodstream (Inside Ralphie) and an exciting exploration through the Ralphiebot Robot to learn about bones, joints and muscles (Flexes its muscles).